Central nervous system delivery of molecules across the blood-brain barrier

Therapies targeting neurological conditions such as Alzheimer's or Parkinson's diseases are hampered by the presence of blood-brain barrier (BBB). During last decades, several approaches have been developed to overcome BBB, use nanoparticles (NPs) based on biomaterials, alternative methods open BBB. In this review, we briefly highlight these strategies and most recent advances in field. Limitations advantages each approach discussed. Combination functionalized NPs receptor-mediated transcytosis system with magnetic resonance imaging-guided focused ultrasound (FUS) might be a promising strategy develop theranostic tools well safely deliver therapeutic molecules, drugs, neurotrophic factors antibodies within brain parenchyma.